Honestly the biggest one I see is weak follow-up after the first purchase. Getting someone to buy once is hard enough but most brands just let them disappear with zero re-engagement and then wonder why retention is terrible
The second biggest is probably bad targeting upstream, wrong people landing on the site in the first place, so even a perfect checkout flow won't save you
Fix the follow-up and fix the ICP and most of the other leaks shrink on their own!